Description

Methyl 3-Amino-4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is a high-value, multifunctional heterocyclic building block characterized by its thiophene core, amino group, phenyl ring, and trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable electronic and physicochemical properties. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as organic semiconductors and non-linear optical (NLO) materials, due to its electron-rich thiophene structure.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new heterocyclic chemistry, facilitating the synthesis of complex molecular architectures.
• Ligand and Catalyst Development: The amino and ester functional groups make it a useful starting material for creating specialized ligands in coordination chemistry and catalysis.

Basic Information

Product Name	Methyl 3-Amino-4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate
CAS No.	256353-38-5
Molecular Formula	C13H10F3NO2S
Molecular Weight	301.29 g/mol
Synonyms	3-Amino-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid methyl ester; Methyl 3-amino-4-phenyl-5-(trifluoromethyl)-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 3-amino-4-phenyl-5-(trifluoromethyl)-, methyl ester; 256353-38-5; 3-Amino-4-phenyl-5-trifluoromethylthiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.