Description

L-Proline, 2-Mercapto- (9Ci) CAS NO 255052-61-0 is a specialized, non-proteinogenic amino acid derivative featuring a thiol (-SH) functional group on the proline backbone. This unique structure makes it a valuable chiral building block and ligand for advanced pharmaceutical synthesis and biochemical research. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications ranging from drug discovery to the development of novel catalysts.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates, particularly those targeting protease enzymes.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for probing protein structure-function relationships.
• Peptide Modification: Incorporated into custom peptides to introduce conformational constraints or metal-binding sites via its thiol group.
• Catalyst Ligand: Acts as a precursor for chiral ligands in asymmetric catalysis for the production of enantiomerically pure compounds.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-Proline, 2-Mercapto- (9Ci)
CAS No.	255052-61-0
Molecular Formula	C5H9NO2S
Molecular Weight	147.19 g/mol
Synonyms	(2S)-2-Mercaptopyrrolidine-2-carboxylic Acid; 2-Mercapto-L-proline; L-2-Mercaptoproline; 2-Thiol-L-proline; (S)-2-Mercaptoproline; 2-SH-L-Proline; 2-Thioproline; NSC 339587
EINECS	Contact for details

Quality Control

Our L-Proline, 2-Mercapto- (9Ci) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.