Description

n-Boc-5-(Hydroxymethyl)-Isoindoline is a protected isoindoline derivative, a versatile and high-purity building block essential for advanced organic synthesis. Its core value lies in providing a reactive hydroxymethyl handle while the tert-butoxycarbonyl (Boc) group offers orthogonal protection for the secondary amine, enabling precise and sequential synthetic strategies. This compound is critically needed by researchers and manufacturers in pharmaceutical development, particularly for constructing complex molecules like kinase inhibitors and other bioactive heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and neurological agents.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a crucial linker component connecting E3 ligase ligands to target protein binders.
• Peptidomimetic Chemistry: Used to incorporate constrained, rigidified isoindoline scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology Probe Synthesis: Enables the creation of tool compounds for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Acts as a precursor for novel herbicide and fungicide candidates with specific modes of action.
• Material Science: Potential monomer for creating specialized polymers with unique thermal or optical properties.

Basic Information

Product Name	n-Boc-5-(Hydroxymethyl)-Isoindoline
CAS No.	253801-14-8
Molecular Formula	C14H19NO3
Molecular Weight	249.31 g/mol
Synonyms	1-Boc-5-(hydroxymethyl)isoindoline; tert-Butyl 5-(hydroxymethyl)isoindoline-2(1H)-carboxylate; 5-(Hydroxymethyl)isoindoline-1-carboxylic acid tert-butyl ester; 2(1H)-Isoindolinecarboxylic acid, 5-(hydroxymethyl)-, 1,1-dimethylethyl ester; N-Boc-5-hydroxymethylisoindoline; 1,1-Dimethylethyl 5-(hydroxymethyl)-2,3-dihydro-1H-isoindole-1-carboxylate
EINECS	Contact for details

Quality Control

Our n-Boc-5-(Hydroxymethyl)-Isoindoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and traceability for demanding research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.