Description

5A-Pregnan-11B,17A,21-Triol-3,20-Dione-1,2,4,5-D4 is a high-purity, deuterium-labeled steroid derivative, serving as a critical reference standard and synthetic intermediate. Its primary value lies in enabling precise analytical quantification and metabolic pathway studies in pharmaceutical research and development. This compound is essential for laboratories and manufacturers in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors focused on steroid hormone analysis and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of related steroid hormones in biological matrices.
• Metabolic Studies: Employed as a stable isotope-labeled tracer to investigate the biotransformation, pharmacokinetics, and metabolic pathways of corticosteroid analogs in preclinical research.
• Synthetic Intermediate: Serves as a key building block in the deuterium-enriched synthesis of more complex steroid molecules for research and development purposes.
• Analytical Method Development: Critical for developing and validating highly sensitive and specific analytical methods in bioanalytical and quality control laboratories.
• Doping Control Analysis: Used in sports anti-doping laboratories as a reference material for the detection of synthetic corticosteroids and their metabolites.
• Clinical Research: Supports studies on endocrine disorders by providing a tool for the precise measurement of steroid levels and their deuterated analogs.

Basic Information

Product Name	5A-Pregnan-11B,17A,21-Triol-3,20-Dione-1,2,4,5-D4
CAS No.	252976-11-7
Molecular Formula	C21H26D4O5
Molecular Weight	Contact for details
Synonyms	11β,17α,21-Trihydroxy-5α-pregnane-3,20-dione-1,2,4,5-d4; Deuterated Tetrahydrocortisone; 5α-Tetrahydrocortisone-d4; (5α)-11β,17,21-Trihydroxypregnane-3,20-dione-1,2,4,5-d4; 5α-Pregnane-3,20-dione-1,2,4,5-d4, 11β,17α,21-trihydroxy-; THF-d4; 5α-THE-d4
EINECS	Contact for details

Quality Control

Every batch of 5A-Pregnan-11B,17A,21-Triol-3,20-Dione-1,2,4,5-D4 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), isotopic purity, and related substance analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.