Description

1-(6-Bromo-3,4-Dihydro-2(1H)-Isoquinolinyl)-2,2,2-Trifluoro-Ethanone is a high-value, advanced pharmaceutical intermediate characterized by its unique trifluoroacetylated isoquinoline scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to incorporate fluorine and bromine functionalities for enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and kinase inhibitors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Serves as a building block for creating novel active ingredients with improved efficacy and environmental profiles.
• Fluorine Chemistry: An important reagent for introducing the trifluoroacetyl group into complex molecules, leveraging the properties of fluorine.
• Chemical Biology Probes: Used in the development of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-(6-Bromo-3,4-Dihydro-2(1H)-Isoquinolinyl)-2,2,2-Trifluoro-Ethanone
CAS No.	252331-63-8
Molecular Formula	C11H9BrF3NO
Molecular Weight	308.10 g/mol
Synonyms	6-Bromo-1-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 2,2,2-Trifluoro-1-(6-bromo-3,4-dihydro-1H-isoquinolin-2-yl)ethan-1-one; 1-(6-Bromo-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2,2-trifluoroethanone; 6-Bromo-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 252331-63-8; Trifluoroacetyl-6-bromotetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 1-(6-Bromo-3,4-Dihydro-2(1H)-Isoquinolinyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full batch traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.