Description

Taurocholic Acid-D4 is a stable isotope-labeled analog of the primary bile acid, taurocholic acid, where four hydrogen atoms are replaced by deuterium. This compound is an essential internal standard and tracer in quantitative mass spectrometry-based analysis, ensuring high accuracy and reproducibility in metabolic studies. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors for advanced analytical applications.

Application

• Mass Spectrometry Internal Standard: Critical for the precise quantification of endogenous taurocholic acid and related bile acids in biological matrices (e.g., serum, plasma, urine) using LC-MS/MS and GC-MS methods.
• Metabolic Pathway Research: Used as a stable isotope tracer to investigate bile acid synthesis, transport, and enterohepatic circulation in preclinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in ADME studies to track the metabolism of drug candidates that affect or are processed by bile acid pathways.
• Diagnostic Assay Development: Serves as a reference standard in the development and validation of clinical diagnostic tests for liver function and cholestatic diseases.
• Biomarker Discovery and Validation: Facilitates accurate profiling of bile acid signatures as potential biomarkers for metabolic disorders, liver disease, and gut microbiome health.
• Quality Control in Pharmaceutical Manufacturing: Used as a certified reference material (CRM) to ensure the accuracy of analytical methods in QC labs for related pharmaceutical products.

Basic Information

Product Name	Taurocholic Acid-D4
CAS No.	252030-90-3
Molecular Formula	C₂₆H₄₁D₄NO₇S
Molecular Weight	515.70 g/mol
Synonyms	2-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl-d4-amino]ethanesulfonic Acid; Deuterated Taurocholic Acid; Taurocholic Acid (d4); Cholyltaurine-d4; N-(3α,7α,12α-Trihydroxy-5β-cholan-24-oyl)-2-aminoethanesulfonic Acid-d4; Taurocholate-d4; TCA-d4
EINECS	Contact for details

Quality Control

Our Taurocholic Acid-D4 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (≥98% D), chemical purity (by HPLC), and confirmation of structure. We adhere to relevant standards for high-purity reference materials to support research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container. Keep container tightly sealed in a dry and cool environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.