Description

(R)-4,5-Isopropylidene-1-Bromopentane is a high-value chiral building block and versatile alkylating agent, essential for the synthesis of complex, optically active molecules. Its core value lies in providing a protected diol functionality and a reactive bromoalkyl handle, enabling precise stereocontrol in multi-step synthetic pathways. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing chiral intermediates, active pharmaceutical ingredients (APIs), and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of antiviral, anticancer, and central nervous system (CNS) active drug candidates.
• Agrochemical Synthesis: Building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and selectivity.
• Asymmetric Catalysis Ligand Precursor: Used in the preparation of chiral phosphines, amines, and other ligands for asymmetric hydrogenation and cross-coupling reactions.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products requiring stereodefined pentane chain fragments.
• Polymer & Material Science: Monomer or cross-linking agent for introducing chirality and functional groups into specialty polymers and advanced materials.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules or creating molecular probes with specific stereochemistry.

Basic Information

Product Name	(R)-4,5-Isopropylidene-1-Bromopentane
CAS No.	251998-53-5
Molecular Formula	C8H15BrO2
Molecular Weight	223.11 g/mol
Synonyms	(R)-1-Bromo-4,5-O-isopropylidene-1-pentane; (R)-1-Bromo-4,5-O-isopropylidenepentane; (R)-4,5-O-Isopropylidene-1-bromopentane; (R)-1-Bromo-4,5-O-(1-methylethylidene)pentane; (R)-1-Bromo-4,5-(isopropylidenedioxy)pentane; (R)-1-Bromo-4,5-acetonide pentane; (R)-4,5-Acetonide-1-bromopentane; (R)-1-Bromopentane-4,5-acetonide
EINECS	Contact for details

Quality Control

Our (R)-4,5-Isopropylidene-1-Bromopentane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC/GC), to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation are provided to guarantee consistency and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.