Description

2'-o-Moe-A(Bz)-3'-Phosphoramidite CAS NO 251647-53-7 is a critical phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound is essential for introducing the 2'-O-methoxyethyl (2'-MOE) modification, which significantly enhances the stability, binding affinity, and nuclease resistance of therapeutic nucleic acids. It is a fundamental building block for research and production in the pharmaceutical and biotechnology industries, particularly for the development of antisense oligonucleotides, siRNA, and other advanced therapeutic modalities.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Primary building block for creating 2'-MOE-modified antisense drugs targeting genetic diseases.
• Therapeutic siRNA Production: Used to synthesize stabilized siRNA strands with improved pharmacokinetic profiles for RNA interference applications.
• Research & Development: Key reagent in academic and industrial labs for studying nucleic acid chemistry and developing novel oligonucleotide-based therapeutics.
• Diagnostic Probe Manufacture: Employed in the production of high-affinity, nuclease-resistant probes for molecular diagnostics and detection assays.
• GMP-Grade Oligonucleotide Manufacturing: Sourced for cGMP-compliant production processes in contract development and manufacturing organizations (CDMOs).
• Aptamer Development: Integral to the synthesis of modified aptamers with enhanced stability for therapeutic and diagnostic use.

Basic Information

Product Name	2'-o-Moe-A(Bz)-3'-Phosphoramidite
CAS No.	251647-53-7
Molecular Formula	C41H49N6O8P
Molecular Weight	784.85 g/mol
Synonyms	5'-O-Dimethoxytrityl-N6-benzoyl-2'-O-(2-methoxyethyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-MOE-A(Bz) Phosphoramidite; 2'-O-MOE Adenosine(Bz) Phosphoramidite; 2'-O-(2-Methoxyethyl)-5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); DMTr-2'-MOE-A(Bz)-CE Phosphoramidite; 2'-MOE A(Bz) Phosphoramidite; 2'-O-Methoxyethyl Adenosine Phosphoramidite (Bz protected)
EINECS	Contact for details

Quality Control

Our 2'-o-Moe-A(Bz)-3'-Phosphoramidite is manufactured under strict quality systems to ensure consistency and reliability for sensitive oligonucleotide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and suitability for automated synthesis. Certificates of Analysis (COA) with full traceability are provided, supporting development under ISO and cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.