Description

Thiazolidine,3-[(2S,3S)-2-Amino-3-Methyl-1-Oxopentyl]-, (2E)-2-Butenedioate (2:1) is a high-purity, non-natural amino acid derivative with a defined stereochemistry. This compound is valued for its role as a key chiral building block and intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and bioactive molecules. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for the synthesis of complex peptides, enzyme inhibitors, and other specialized organic compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in peptide-based drug discovery.
• Peptide Synthesis: Used as a protected or modified amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce specific structural features.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for stereoisomer separation.
• Agrochemical Development: Employed as a building block in the synthesis of advanced, chiral agrochemicals with targeted biological activity.
• Fine Chemical Synthesis: A versatile intermediate for constructing complex molecular architectures in custom synthesis and process chemistry.
• Ligand and Catalyst Development: Utilized in the design and synthesis of chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	Thiazolidine,3-[(2S,3S)-2-Amino-3-Methyl-1-Oxopentyl]-, (2E)-2-Butenedioate (2:1)
CAS No.	251572-86-8
Molecular Formula	C13H22N2O5S · C4H4O4
Molecular Weight	Contact for details
Synonyms	(2S,3S)-2-Amino-3-methylpentanoic acid thiazolidine derivative fumarate (2:1); L-allo-Isoleucine thiazolidine derivative fumarate salt; 3-[(2S,3S)-2-Amino-3-methyl-1-oxopentyl]thiazolidine fumarate (2:1); Fumaric acid, compd. with 3-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]thiazolidine (2:1); Thiazolidine-3-carboxylic acid derivative fumarate salt; Chiral thiazolidine amino acid fumarate; Non-proteinogenic amino acid intermediate.
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, assay, and impurity profiles. While typically supplied as a research-grade material, synthesis can be conducted under GMP-like conditions upon request for advanced pharmaceutical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.