Description

3-([3-(Trifluoromethyl)Benzyl]Sulfanyl)-2-Thiophenecarboxylic Acid is a high-value, multi-functional heterocyclic building block featuring a thiophene carboxylic acid core linked to a trifluoromethyl-substituted benzylthio moiety. This compound matters for its unique structural combination, offering a versatile scaffold for introducing both lipophilic and electron-withdrawing characteristics into target molecules, which is critical for modulating physicochemical properties in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly for introducing the trifluoromethyl and thiophene pharmacophores.
• Agrochemical Synthesis: Used in the design and synthesis of advanced pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Material Science Research: Acts as a precursor for functionalized monomers or ligands in the development of specialty polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Employed in the construction of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-([3-(Trifluoromethyl)Benzyl]Sulfanyl)-2-Thiophenecarboxylic Acid
CAS No.	251096-78-3
Molecular Formula	C13H9F3O2S2
Molecular Weight	318.33 g/mol
Synonyms	3-[(3-Trifluoromethylbenzyl)thio]thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 3-[[[3-(trifluoromethyl)phenyl]methyl]thio]-; 3-((3-(Trifluoromethyl)benzyl)thio)thiophene-2-carboxylic acid; α-(Trifluoromethyl)-3-thienylmercaptotoluene-2-carboxylic acid; 3-(3-Trifluoromethylbenzylsulfanyl)thiophene-2-carboxylic acid; 3-[(3-Trifluoromethylphenyl)methanethio]thiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-([3-(Trifluoromethyl)Benzyl]Sulfanyl)-2-Thiophenecarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.