Description

2-(2,5-Dioxo-1-Pyrrolidinyl)-4-Pyridinecarboxylicacidethylester is a high-purity chemical building block featuring a pyridine core functionalized with a maleimide ester group. This molecular structure makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for creating targeted drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Bioconjugation Reagent: Used to modify proteins, antibodies, or peptides via its reactive maleimide group, which selectively binds to thiols.
• Linker Chemistry: Serves as a versatile linker in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Polymer Modification: Employed to introduce functional pyridine or maleimide groups into polymer backbones for specialty materials.
• Chemical Biology Probes: Utilized in the creation of probes for studying enzyme activity or protein-protein interactions.
• Organic Synthesis Building Block: A versatile intermediate for constructing heterocyclic compounds and complex molecular architectures.

Basic Information

Product Name	2-(2,5-Dioxo-1-Pyrrolidinyl)-4-Pyridinecarboxylicacidethylester
CAS No.	250160-11-3
Molecular Formula	C13H12N2O5
Molecular Weight	276.25 g/mol
Synonyms	4-Pyridinecarboxylic acid, 2-(2,5-dioxo-1-pyrrolidinyl)-, ethyl ester; Ethyl 2-(2,5-dioxopyrrolidin-1-yl)isonicotinate; 2-(2,5-Dioxopyrrolidin-1-yl)isonicotinic acid ethyl ester; 1-(4-(Ethoxycarbonyl)pyridin-2-yl)-1H-pyrrole-2,5-dione; Maleimide-Pyridine Ester; N-(4-Carbethoxypyrid-2-yl)maleimide
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dioxo-1-Pyrrolidinyl)-4-Pyridinecarboxylicacidethylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.