Description

(3-Bromophenethoxy)(tert-Butyl)Dimethylsilane is a high-purity organosilicon reagent featuring a brominated aromatic moiety protected by a tert-butyldimethylsilyl (TBDMS) ether group. This compound is a critical building block in advanced organic synthesis, valued for its role in introducing protected phenethyl alcohol derivatives into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs), ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, particularly in CNS and oncology research where the bromophenethyl structure is pharmacologically relevant.
• Agrochemical Synthesis: Used in constructing advanced pesticide and herbicide molecules that require halogenated aromatic components.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or nitrogen-based ligands used in asymmetric catalysis.
• Polymer and Material Science: Incorporated into monomers for producing specialty polymers with specific optical or electronic properties.
• Peptide Mimetics and Bioconjugation: The protected hydroxyl group allows for selective deprotection and further functionalization in peptide chemistry.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	(3-Bromophenethoxy)(tert-Butyl)Dimethylsilane
CAS No.	249937-07-3
Molecular Formula	C14H23BrOSi
Molecular Weight	315.33 g/mol
Synonyms	2-(3-Bromophenyl)ethyl tert-butyldimethylsilyl ether; 1-Bromo-3-[2-[(tert-butyldimethylsilyl)oxy]ethyl]benzene; 3-Bromophenethyl TBDMS ether; tert-Butyl(2-(3-bromophenyl)ethoxy)dimethylsilane; 2-(3-Bromophenyl)ethanol TBDMS ether; TBDMS ether of 3-bromophenethyl alcohol; (3-Bromophenethyloxy)(tert-butyl)dimethylsilane
EINECS	Contact for details

Quality Control

Our (3-Bromophenethoxy)(tert-Butyl)Dimethylsilane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.