Description

Thiophene, 2-(Difluoromethyl)-2-Fluorotetrahydro- (9Ci) is a specialized fluorinated thiophene derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring both difluoromethyl and fluoro substituents on a saturated thiophene ring, makes it a critical intermediate for introducing fluorine motifs into target molecules, which is essential for modulating their physicochemical and biological properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity, metabolic stability, and biological activity.
• Material Science Research: Serves as a precursor for developing novel fluorinated polymers, liquid crystals, and electronic materials with tailored properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, ring-opening transformations, and as a scaffold for constructing complex, fluorinated heterocyclic compounds in academic and industrial R&D settings.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the reactivity and stability of gem-difluoromethyl and fluoro groups within a saturated heterocyclic system.

Basic Information

Product Name	Thiophene, 2-(Difluoromethyl)-2-Fluorotetrahydro- (9Ci)
CAS No.	249935-43-1
Molecular Formula	C6H7F3S
Molecular Weight	168.18 g/mol
Synonyms	2-(Difluoromethyl)-2-fluorotetrahydrothiophene; Tetrahydro-2-(difluoromethyl)-2-fluorothiophene; 2-Fluoro-2-(difluoromethyl)tetrahydrothiophene; 249935-43-1; AI3-63200; AKOS040759424; F2198-0409; SCHEMBL21842227; ZINC000253909996
EINECS	Contact for details

Quality Control

Every batch of Thiophene, 2-(Difluoromethyl)-2-Fluorotetrahydro- (9Ci) is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.