Description

Hs-Peg5-Oh CAS NO 248582-03-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group at one terminus and a thiol-reactive group at the other. This compound is a critical functional linker and spacer molecule, enabling the precise conjugation of biomolecules, nanoparticles, and surfaces in advanced research and development. It is essential for scientists and engineers in the pharmaceutical, bioconjugation, and materials science sectors who require reliable, well-defined PEGylation reagents to improve solubility, reduce immunogenicity, and create stable, functionalized constructs.

Application

• Bioconjugation and PEGylation: Used to attach therapeutic proteins, peptides, or antibodies to other molecules or surfaces while introducing beneficial PEG properties.
• Drug Delivery System Development: Serves as a key component in constructing targeted drug delivery platforms, such as antibody-drug conjugates (ADCs) and nanoparticle formulations.
• Surface Functionalization: Employed to modify gold nanoparticles, quantum dots, and other material surfaces with a hydroxyl-terminated PEG layer for improved biocompatibility and further coupling.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker in hydrogel formation and polymer network synthesis for biomedical applications.
• Diagnostic Reagent Synthesis: Utilized in the development of diagnostic assays and imaging probes where specific, stable conjugation is required.
• Biomaterial Engineering: Incorporated into scaffolds and coatings to enhance biointerface properties and control cell-material interactions.

Basic Information

Product Name	Hs-Peg5-Oh
CAS No.	248582-03-8
Molecular Formula	C14H28O7S
Molecular Weight	340.43 g/mol
Synonyms	HS-PEG5-OH; Thiol-PEG5-alcohol; 11-Mercapto-3,6,9-trioxaundecan-1-ol; 2,5,8,11-Tetraoxatridecane-13-thiol; 3,6,9-Trioxa-11-mercaptoundecyl alcohol; Heterobifunctional PEG, Thiol and Hydroxy terminated; α-Thiol-ω-hydroxy pentaethylene glycol; PEG5 dithiol monoalcohol
EINECS	Contact for details

Quality Control

Our Hs-Peg5-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	340.43 ± 2

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.