Description

1-n-Glycidyl-5-Fluoro-Indole is a high-value, multi-functional chemical building block featuring a reactive glycidyl ether group and a fluorinated indole core. This compound is critical for the synthesis of advanced pharmaceutical intermediates and fine chemicals, enabling the introduction of both fluorinated and epoxide functionalities into target molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the biological activity of the fluorinated indole scaffold.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functional polymers and advanced organic electronic materials due to its conjugated system and reactive handle.
• Fluorine Chemistry: An essential reagent for introducing fluorine atoms into complex organic molecules, a common strategy in modern medicinal chemistry to modulate pharmacokinetics.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions to construct more complex heterocyclic systems.

Basic Information

Item	Detail
Product Name	1-n-Glycidyl-5-Fluoro-Indole
CAS No.	247915-89-5
Molecular Formula	C11H10FNO2
Molecular Weight	207.20 g/mol
Synonyms	5-Fluoro-1-(oxiran-2-ylmethyl)-1H-indole; 1-Glycidyl-5-fluoroindole; 1-(Oxiranylmethyl)-5-fluoro-1H-indole; 5-Fluoro-1H-indole-1-glycidyl; 1H-Indole-1-glycidyl, 5-fluoro-; 1-(2,3-Epoxypropyl)-5-fluoroindole; 5-Fluoro-1-(2,3-epoxypropyl)indole; Glycidyl 5-fluoro-1H-indole-1-yl ether
EINECS	Contact for details

Quality Control

Every batch of 1-n-Glycidyl-5-Fluoro-Indole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via HPLC, NMR, and GC-MS is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from oxidizing agents and strong bases. Due to its light-sensitive and easily oxidized nature, minimize exposure to air and light during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.