Description

3-(Fluoromethyl)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise introduction of the sulfonamide pharmacophore, a key structural motif for modulating biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel small molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the sulfonamide group enhances binding affinity and selectivity.
• Chemical Biology Probe Development: Employed to create activity-based probes (ABPs) and affinity labels for studying enzyme function and target identification.
• Material Science Research: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers with unique surface properties or controlled release capabilities.
• Peptidomimetic Chemistry: Facilitates the construction of non-peptide scaffolds that mimic the structure and function of bioactive peptides.
• Library Synthesis for High-Throughput Screening (HTS): A valuable reagent for generating diverse compound libraries to identify new hits in drug discovery campaigns.

Basic Information

Item	Details
Product Name	3-(Fluoromethyl)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonyl Chloride
CAS No.	247050-23-3
Molecular Formula	C10H9ClFNO3S
Molecular Weight	277.70 g/mol
Synonyms	7-(Chlorosulfonyl)-3-(fluoromethyl)-3,4-dihydro-1H-isoquinolin-1-one; 3-(Fluoromethyl)-1-oxo-3,4-dihydroisoquinoline-7-sulfonyl chloride; 1,2,3,4-Tetrahydro-3-(fluoromethyl)-1-oxo-7-isoquinolinesulfonyl chloride; 247050-23-3; 3-Fluoromethyl-1-oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-(Fluoromethyl)-1-Oxo-1,2,3,4-Tetrahydroisoquinoline-7-Sulfonyl Chloride is manufactured and tested under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.