Description

Weinreb Linker CAS NO 247021-90-5 is a specialized chemical reagent, specifically a Weinreb amide derivative, designed for efficient and selective synthesis. Its core value lies in its pivotal role as a versatile intermediate in modern organic and medicinal chemistry, enabling the controlled formation of ketones and aldehydes from carboxylic acid derivatives. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing complex carbonyl-containing scaffolds.
• Peptide & Protein Chemistry: Used in the synthesis of modified peptides and as a handle for bioconjugation strategies.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the creation of specialized polymers, ligands, and organic electronic materials.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and catalysis studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise ketone or aldehyde introduction.

Basic Information

Product Name	Weinreb Linker
CAS No.	247021-90-5
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	2-(((2,2,2-Trifluoroethoxy)carbonyl)amino)acetic acid; N-(Carboxymethyl)-2,2,2-trifluoroethoxycarboxamide; TFAOC-Gly-OH; Glycine, N-[(2,2,2-trifluoroethoxy)carbonyl]-; CF3CH2OC(O)NHCH2COOH; Troc-Glycine derivative; 2,2,2-Trifluoroethyl Glycine Carbamate; Glycine, N-[(trifluoroethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Weinreb Linker is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.