Description

-Histine-D3 is a high-purity, deuterium-labeled isotopologue of the amino acid histidine, specifically designed for advanced analytical and research applications. This compound is essential for use as an internal standard in mass spectrometry-based quantitative analysis, ensuring unparalleled accuracy and reliability in measurement. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolomics, proteomics, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of endogenous histidine and related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolomics Research: Enables accurate tracking and quantification in studies of amino acid metabolism, biomarker discovery, and metabolic pathway analysis.
• Pharmaceutical Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to monitor the stability and catabolism of protein-based therapeutics and peptides containing histidine.
• Stable Isotope Labeling: Acts as a tracer in metabolic flux analysis to investigate real-time biochemical processes within cells and organisms.
• Nutritional Science Research: Facilitates the study of histidine requirements, absorption, and utilization in clinical and preclinical nutritional studies.
• Quality Control in Amino Acid Analysis: Provides a benchmark for ensuring the accuracy and precision of analytical methods in quality control laboratories for amino acid supplements or infusion solutions.

Basic Information

Product Name	-Histine-D3
CAS No.	244094-70-0
Molecular Formula	C6H6D3N3O2
Molecular Weight	158.17 g/mol
Synonyms	L-Histidine-D3; Histidine (imidazole-2,4,5-D3); (2S)-2-Amino-3-(1H-imidazole-2,4,5-D3-5-yl)propanoic acid; Histidine-d3; Deuterated Histidine; Histidine Internal Standard; Histidine (2,4,5-D3); FEMA 3694
EINECS	Contact for details

Quality Control

Every batch of -Histine-D3 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D%), and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.