Description

tert-Butyl 3-(Hydroxymethyl)-3,4-Dihydro-1H-Isoquinoline-2-Carboxylate CAS NO 243858-66-4 is a high-purity, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its dual functionality, featuring both a hydroxymethyl group and a tert-butyloxycarbonyl (Boc) protecting group, which provides versatility in multi-step synthetic routes. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex isoquinoline-based drug candidates and bioactive molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetic Synthesis: Used in the construction of constrained peptide analogs and non-peptidic scaffolds that mimic peptide structure and function.
• Alkaloid Synthesis: An important building block for the total or semi-synthesis of complex natural products and alkaloids containing the tetrahydroisoquinoline core.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	tert-Butyl 3-(Hydroxymethyl)-3,4-Dihydro-1H-Isoquinoline-2-Carboxylate
CAS No.	243858-66-4
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 1,2,3,4-Tetrahydro-3-(hydroxymethyl)-2-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; Boc-3-(hydroxymethyl)-THIQ; 243858-66-4; 2-(tert-Butoxycarbonyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Hydroxymethyl)-3,4-Dihydro-1H-Isoquinoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring material traceability and reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong acids and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.