Description

25,26,26,26,27,27,27-Heptafluoro-7-Hydroxycholesterol is a high-value, fluorinated derivative of cholesterol, distinguished by the strategic substitution of hydrogen atoms with fluorine at the terminal positions of the side chain. This specific fluorination pattern is critical for modifying the compound's lipophilicity, metabolic stability, and binding affinity, making it an essential advanced intermediate for research and development. It is primarily sought after by pharmaceutical and biotechnology companies for applications in drug discovery, particularly in the study of lipid metabolism, membrane biology, and as a precursor for novel therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel fluorinated steroid analogs with potential therapeutic applications.
• Biochemical Research: Used as a probe or standard in studies investigating cholesterol metabolism, membrane fluidity, and protein-lipid interactions due to its modified physicochemical properties.
• Drug Discovery: Serves as a critical intermediate in medicinal chemistry programs aiming to develop drugs targeting nuclear receptors (e.g., Liver X Receptors) or pathways involving cholesterol.
• Diagnostic Agent Development: Potential precursor for radiolabeled (e.g., with 18F) compounds used in Positron Emission Tomography (PET) imaging.
• Material Science: Exploration of its use in creating advanced biomaterials or surface modifiers where fluorinated cholesterol derivatives can alter self-assembly properties.

Basic Information

Item	Detail
Product Name	25,26,26,26,27,27,27-Heptafluoro-7-Hydroxycholesterol
CAS No.	240129-42-4
Molecular Formula	C27H39F7O2
Molecular Weight	528.59 g/mol
Synonyms	7-Hydroxy-25,26,26,26,27,27,27-heptafluorocholesterol; Heptafluorocholesterol derivative; 25,26,26,26,27,27,27-Heptafluoro-7β-hydroxycholesterol; Fluorinated cholesterol intermediate; (3β)-25,26,26,26,27,27,27-Heptafluorocholest-5-en-7-ol; 7-Hydroxy-heptafluorocholesterol; 240129-42-4
EINECS	Contact for details

Quality Control

Our 25,26,26,26,27,27,27-Heptafluoro-7-Hydroxycholesterol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under controlled conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.