Description

2-Chloro-5-(Trifluoromethyl)Benzyl Bromide is a versatile and highly reactive benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive benzylic bromide handle with chloro and trifluoromethyl substituents, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require high-purity intermediates for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing aryl-alkyl ethers or amines.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a starting material for constructing specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of functionalized monomers or additives for advanced polymers with specific optical or electronic properties.
• Chemical Biology Probes: Useful for the alkylation of biomolecules or the synthesis of molecular probes for studying biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Benzyl Bromide
CAS No.	237761-77-2
Molecular Formula	C8H5BrClF3
Molecular Weight	273.48 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-5-(trifluoromethyl)benzene; α-Bromo-2-chloro-α,α,α-trifluoro-p-xylene; 2-Chloro-α-(bromomethyl)benzotrifluoride; (2-Chloro-5-(trifluoromethyl)phenyl)methyl bromide; 2-Chloro-5-trifluoromethylbenzyl bromide; Benzene, 1-(bromomethyl)-2-chloro-5-(trifluoromethyl)-; p-Xylene, α-bromo-2-chloro-α,α,α-trifluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethyl)Benzyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.