Description

Methyl 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its core value lies in the strategic combination of a thiophene core, a phenyl ring, and a trifluoromethyl group, offering unique electronic and steric properties for modulating molecular activity and stability. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate in the development of novel active ingredients, particularly for candidates targeting CNS disorders and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new chemical entities (NCEs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl-thiophene moiety enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, including semiconductors and non-linear optical (NLO) materials.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) in fluorinated heterocycles.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific target molecules.

Basic Information

Product Name	Methyl 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate
CAS No.	237385-98-7
Molecular Formula	C13H9F3O2S
Molecular Weight	286.27 g/mol
Synonyms	Methyl 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylate; 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic Acid Methyl Ester; Methyl 5-(Trifluoromethyl)-4-phenylthiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 4-phenyl-5-(trifluoromethyl)-, methyl ester; MFCD11871103
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate adheres to stringent in-process controls and final batch release testing to ensure consistent purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality management system is designed to support cGMP and ISO standards for traceability and reliability, making this material suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.