Description

(S)-(+)-4-Benzyl-3-Benzyloxyacetyl-2-Oxazolidinone CAS NO 236110-81-9 is a high-purity chiral auxiliary and synthetic building block of significant importance in asymmetric organic synthesis. Its value lies in its ability to induce high stereoselectivity in key bond-forming reactions, enabling the production of enantiomerically pure intermediates. This compound is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex, biologically active molecules.

Application

• Asymmetric Synthesis: As a versatile Evans-type chiral auxiliary for diastereoselective alkylation, aldol, and Michael addition reactions.
• Pharmaceutical Intermediates: Key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and cardiovascular drugs.
• Peptidomimetics & Amino Acid Derivatives: Used in the preparation of non-natural amino acids and peptide analogs with defined stereochemistry.
• Catalyst & Ligand Development: Serves as a precursor for novel chiral catalysts and ligands used in homogeneous catalysis.
• Process Chemistry & Scale-up: Employed in the development and optimization of robust, scalable manufacturing routes for chiral compounds.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic chemistry and for creating compound libraries for drug discovery.

Basic Information

Product Name	(S)-(+)-4-Benzyl-3-Benzyloxyacetyl-2-Oxazolidinone
CAS No.	236110-81-9
Molecular Formula	C19H19NO4
Molecular Weight	325.36 g/mol
Synonyms	(S)-4-Benzyl-3-[(benzyloxy)acetyl]-2-oxazolidinone; (S)-(+)-4-Benzyl-3-(benzyloxyacetyl)-2-oxazolidinone; (S)-4-Benzyl-3-(benzyloxyacetyl)oxazolidin-2-one; Evans Auxiliary Derivative; (S)-BOA-Oxazolidinone; N-[(Benzyloxy)acetyl]-4-benzyl-2-oxazolidinone, (S)-; Benzyl (S)-4-benzyl-2-oxo-3-oxazolidineacetate
EINECS	Contact for details

Quality Control

Our (S)-(+)-4-Benzyl-3-Benzyloxyacetyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We support compliance with cGMP and ISO guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.