Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-3-Fluoro-, (1R,2S,3S,5S,6R)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its rigid, three-dimensional scaffold which is instrumental in designing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of new therapeutic agents, particularly in areas requiring precise molecular geometry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Protease Inhibitor Development: Its constrained bicyclic structure mimics peptide turn motifs, making it valuable for designing inhibitors of proteolytic enzymes.
• Peptidomimetics & Conformationally Restricted Peptides: Used to introduce rigidity into peptide chains to enhance metabolic stability, potency, and selectivity.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and as a molecular probe to explore protein-ligand interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material for the enantioselective construction of other complex molecules.
• Ligand Synthesis for Catalysis: Potential precursor for novel chiral ligands used in asymmetric catalysis.

Basic Information

Item	Detail
Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-3-Fluoro-, (1R,2S,3S,5S,6R)-Rel- (9Ci)
CAS No.	234085-19-9
Molecular Formula	C9H10FNO4
Molecular Weight	215.18 g/mol
Synonyms	(1R,2S,3S,5S,6R)-2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; rel-(1R,2S,3S,5S,6R)-2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (stereoisomer); Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, (1R,2S,3S,5S,6R)-rel-; 234085-19-9; Fluorinated Bicyclic Amino Acid; 3-Fluoro-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-3-Fluoro-, (1R,2S,3S,5S,6R)-Rel- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.