Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-3-Fluoro-, (1R,2R,3S,5S,6R)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique constrained structure and functional groups make it invaluable for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery, particularly in the development of novel protease inhibitors, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in antiviral and neurological drug candidates.
• Peptidomimetics & Constrained Peptide Design: Used to introduce rigid, bicyclic scaffolds into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Protease Inhibitor Development: The fluorine-substituted, amino-dicarboxylic acid structure is highly relevant for designing transition-state analogs targeting various protease enzymes.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Chemical Biology & Bioconjugation: Utilized in probe and tool compound synthesis for studying biological pathways and protein interactions.
• Material Science Research: Potential building block for advanced polymers and functional materials with specific stereochemical properties.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-3-Fluoro-, (1R,2R,3S,5S,6R)-Rel- (9Ci)
CAS No.	234085-14-4
Molecular Formula	C9H10FNO4
Molecular Weight	215.18 g/mol
Synonyms	(1R,2R,3S,5S,6R)-2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; rel-(1R,2R,3S,5S,6R)-2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (rel-(1R,2R,3S,5S,6R)-); Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, (1R,2R,3S,5S,6R)-rel-; 234085-14-4; Fluorinated Bicyclic Amino Acid
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-3-Fluoro-, (1R,2R,3S,5S,6R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.