Description

5-Fluoro-3,4-dihydro-1(2H)-isoquinolinone is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its role as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine atom and isoquinolinone scaffold can impart desirable biological activity and stability.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its rigid, fused-ring structure.
• Chemical Biology: Employed as a probe or labeling agent in biochemical research to study enzyme mechanisms or protein interactions.
• Academic & Contract Research: Utilized in universities and CROs (Contract Research Organizations) for method development and exploratory chemistry projects.
• Custom Synthesis: A starting point for the contract manufacturing of more complex, customer-specific fluorinated compounds.

Basic Information

Product Name	5-Fluoro-3,4-dihydro-1(2H)-isoquinolinone
CAS No.	230301-83-4
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydroisoquinolin-1-one; 5-Fluoro-3,4-dihydro-2H-isoquinolin-1-one; 5-Fluoro-1-oxo-1,2,3,4-tetrahydroisoquinoline; 5-Fluoro-1-tetralone imide; 230301-83-4; 5-Fluoro-1-isoquinolinone, 3,4-dihydro-; 5-Fluoro-3,4-dihydroisoquinolin-1(2H)-one
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3,4-dihydro-1(2H)-isoquinolinone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.