Description

Retigabine n-β-D-Glucoside is a glucuronide metabolite of the active pharmaceutical ingredient retigabine (ezogabine). This compound is of significant interest in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It serves as a critical reference standard and intermediate for analytical method development and bioanalytical validation. This high-purity material is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on neuroscience and drug metabolism.

Application

• Primary use as a reference standard for the quantification of retigabine metabolites in biological matrices.
• Critical intermediate in the analytical method development and validation for bioequivalence and pharmacokinetic studies.
• Used in pharmaceutical research to study the metabolic pathways and clearance mechanisms of retigabine.
• Essential material for quality control laboratories in the production of retigabine-based active pharmaceutical ingredients (APIs).
• Valuable tool in preclinical and clinical development stages for neurological drug candidates.
• Serves as a building block or precursor in the synthesis of labeled analogs (e.g., deuterated or C13-labeled) for advanced mass spectrometry studies.

Basic Information

Product Name	Retigabine n-β-D-Glucoside
CAS No.	229970-69-8
Molecular Formula	C20H25FN2O7
Molecular Weight	424.42 g/mol
Synonyms	N-[(2-Amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamoyl]-β-D-glucopyranosiduronic acid; Retigabine Glucuronide; Retigabine N-Glucuronide; Ezogabine N-Glucuronide; N-Glucuronyl retigabine; AWD 32-232 Glucuronide; 229970-69-8; N-β-D-Glucopyranosiduronic acid, N-[(2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl)carbamoyl]-
EINECS	Contact for details

Quality Control

Our Retigabine n-β-D-Glucoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, impurities, and batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.