Description

5-[5-(Trifluoromethyl)Isoxazol-3-Yl]Thiophene-2-Sulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and chemical building block. This compound is valued for its unique heterocyclic structure, which combines an isoxazole ring bearing a trifluoromethyl group with a thiophene sulfonyl chloride moiety, making it a versatile synthon for medicinal chemistry and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in areas targeting enzyme inhibition and receptor modulation.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl-isoxazole-thiophene scaffold.
• Chemical Synthesis Reagent: The reactive sulfonyl chloride group makes it an excellent electrophile for introducing the sulfonamide or sulfonate functional group into more complex molecules.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Bioconjugation & Probe Development: Useful for labeling biomolecules or creating chemical probes for biochemical and diagnostic applications.

Basic Information

Item	Details
Product Name	5-[5-(Trifluoromethyl)Isoxazol-3-Yl]Thiophene-2-Sulfonyl Chloride
CAS No.	229956-98-3
Molecular Formula	C8H3ClF3NO3S2
Molecular Weight	317.69 g/mol
Synonyms	5-(5-Trifluoromethyl-3-isoxazolyl)thiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-[5-(trifluoromethyl)-3-isoxazolyl]-; 5-(5-(Trifluoromethyl)isoxazol-3-yl)thiophene-2-sulfonyl chloride; 229956-98-3; 5-(5-Trifluoromethylisoxazol-3-yl)thiophene-2-sulfonyl chloride; 3-(5-Chlorosulfonyl-2-thienyl)-5-(trifluoromethyl)isoxazole
EINECS	Contact for details

Quality Control

Our 5-[5-(Trifluoromethyl)Isoxazol-3-Yl]Thiophene-2-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to meeting the stringent requirements of our global clientele in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.