Description

6-Iodo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-value, synthetically versatile heterocyclic building block. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key intermediate in the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable tetrahydroisoquinoline scaffold.
• Peptidomimetic Development: Serves as a constrained amino acid analog for designing novel peptides with enhanced metabolic stability and bioavailability.
• Library Synthesis: Employed in combinatorial and parallel synthesis to generate diverse chemical libraries for high-throughput screening.
• Agrochemical Research: Acts as a building block for developing new active ingredients in crop protection science.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study biological pathways and protein interactions.

Basic Information

Product Name	6-Iodo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	228728-11-8
Molecular Formula	C10H10INO2
Molecular Weight	303.10 g/mol
Synonyms	6-Iodo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 3-Carboxy-6-iodo-1,2,3,4-tetrahydroisoquinoline; 6-Iodo-THIQ-3-COOH; 6-Iodo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-6-Iodo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (for enantiopure form); 6-Iodo-3-isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-; 228728-11-8
EINECS	Contact for details

Quality Control

Every batch of 6-Iodo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.