Description

(3-(2-((tert-Butyldiphenylsilyl)Oxy)Ethoxy)Phenyl)Boronic Acid is a sophisticated, multi-functional organoboronic acid derivative, serving as a critical synthetic intermediate. Its core value lies in its dual functionality, combining a protected hydroxyl group with a boronic acid moiety, enabling precise cross-coupling reactions and complex molecule construction. This compound is essential for researchers and manufacturers in pharmaceutical development and advanced material science, particularly for creating novel active pharmaceutical ingredients (APIs) and functional organic frameworks.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in drug candidates.
• API Synthesis: Used in the research and development of new Active Pharmaceutical Ingredients (APIs), especially for oncology and central nervous system (CNS) therapeutics.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Utilized to develop molecular probes and sensors that leverage boronic acid-diol interactions for detection and imaging.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical industry.

Basic Information

Product Name	(3-(2-((tert-Butyldiphenylsilyl)Oxy)Ethoxy)Phenyl)Boronic Acid
CAS No.	227306-39-0
Molecular Formula	C24H29BO4Si
Molecular Weight	420.39 g/mol
Synonyms	[3-[2-[(1,1-Dimethylethyl)diphenylsilyl]oxyethoxy]phenyl]boronic acid; 3-[2-(tert-Butyldiphenylsilyloxy)ethoxy]benzeneboronic acid; (3-(2-(tert-Butyldiphenylsilyloxy)ethoxy)phenyl)boronic acid; TBDPS-protected PEG-phenylboronic acid; 3-(2-((tert-Butyldiphenylsilyl)oxy)ethoxy)benzeneboronic acid; Boronic acid, B-[3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethoxy]phenyl]-; CAS 227306-39-0
EINECS	Contact for details

Quality Control

Our production of (3-(2-((tert-Butyldiphenylsilyl)Oxy)Ethoxy)Phenyl)Boronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key parameters to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.