Description

L-Phenyl-D5-Alanine-n-Fmoc CAS NO 225918-67-2 is a deuterium-labeled, N-Fmoc-protected derivative of the essential amino acid phenylalanine, specifically designed for advanced research and development. This high-purity, isotopically labeled building block is critical for creating peptides with enhanced metabolic stability and traceability in analytical studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug discovery, proteomics, and pharmacokinetic research.

Application

• Deuterated Peptide Synthesis: As a key protected amino acid for the solid-phase and solution-phase synthesis of deuterium-labeled peptides and peptidomimetics.
• Mass Spectrometry Standards: Used as an internal standard or a stable isotope-labeled precursor in quantitative LC-MS/MS and proteomic analyses for accurate quantification.
• Drug Metabolism & Pharmacokinetics (DMPK): Incorporated into drug candidates to study absorption, distribution, metabolism, and excretion (ADME) pathways with minimal isotopic interference.
• Biochemical Tracing: Enables the tracing of phenylalanine incorporation and metabolic fate in complex biological systems and in vitro assays.
• Structural Biology & NMR Studies: The deuterium labels facilitate nuclear magnetic resonance (NMR) spectroscopy by simplifying complex spectra in protein structural analysis.
• High-Value API Intermediate: Serves as a sophisticated building block in the research-scale synthesis of novel therapeutic peptides and targeted radiopharmaceuticals.

Basic Information

Product Name	L-Phenyl-D5-Alanine-n-Fmoc
CAS No.	225918-67-2
Molecular Formula	C24H20D5NO4
Molecular Weight	~403.5 g/mol
Synonyms	Fmoc-Phe(D5)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine-3,3,4,5,5-D5; Fmoc-L-phenylalanine-d5; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-(phenyl-3,4,5,6-d4)propanoic acid; Fmoc-Phenylalanine(D5); N-Fmoc-L-phenylalanine-d5; Deuterated Fmoc-Phenylalanine; L-Phenylalanine-D5, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Every batch of L-Phenyl-D5-Alanine-n-Fmoc is manufactured and tested under strict quality systems to ensure exceptional isotopic and chemical purity for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (D-content), chemical purity by HPLC, chiral purity, and residual solvent content. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.