Description

7-Bromo-1,2,3,4-tetrahydro-3-(trifluoromethyl)-isoquinoline is a high-value, multi-functional heterocyclic building block that serves as a critical intermediate in advanced organic synthesis. Its unique structure, featuring both bromine and trifluoromethyl substituents on a tetrahydroisoquinoline scaffold, makes it indispensable for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for central nervous system (CNS) drug discovery, cancer research, and the development of enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating novel organic ligands, catalysts, and functional materials with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs) developing proprietary compounds.

Basic Information

Item	Details
Product Name	7-Bromo-1,2,3,4-tetrahydro-3-(trifluoromethyl)-isoquinoline
CAS No.	223916-04-9
Molecular Formula	C₁₀H₉BrF₃N
Molecular Weight	280.09 g/mol
Synonyms	7-Bromo-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline; 3-(Trifluoromethyl)-7-bromo-1,2,3,4-tetrahydroisoquinoline; 7-Bromo-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 223916-04-9; 7-Br-3-CF3-THIQ; 7-Bromo-3-(trifluoromethyl)-THIQ
EINECS	Contact for details

Quality Control

Our production of 7-Bromo-1,2,3,4-tetrahydro-3-(trifluoromethyl)-isoquinoline adheres to stringent in-process controls and final batch testing to ensure consistent high purity and reliable performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous demands of research and development applications, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.