Description

(2S,4R,5S)-(-)-2,5-Diphenyl-3,4-Dimethyl-1,3,2-Oxazaphospholidine-2-Borane CAS NO 223758-04-1 is a chiral, non-racemic organophosphorus compound complexed with borane, serving as a highly effective and selective chiral auxiliary or ligand in asymmetric synthesis. Its value lies in enabling the production of enantiomerically pure intermediates critical for advanced pharmaceutical and agrochemical research. This compound is essential for chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors who require precise stereochemical control in catalytic and stoichiometric transformations.

Application

• Asymmetric Catalysis: Employed as a chiral ligand for transition metal catalysts in enantioselective hydrogenation, hydroboration, and cross-coupling reactions.
• Pharmaceutical Intermediate Synthesis: Crucial for the stereocontrolled synthesis of chiral active pharmaceutical ingredients (APIs) and complex natural products.
• Chiral Auxiliary: Used in stoichiometric asymmetric induction for the synthesis of enantiomerically enriched alcohols, amines, and other functional groups.
• Agrochemical Research: Applied in the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Investigated for the preparation of chiral polymers and advanced materials with specific optical properties.
• Academic & Process R&D: A valuable tool in university laboratories and industrial R&D for developing new asymmetric methodologies.

Basic Information

Product Name	(2S,4R,5S)-(-)-2,5-Diphenyl-3,4-Dimethyl-1,3,2-Oxazaphospholidine-2-Borane
CAS No.	223758-04-1
Molecular Formula	C₁₇H₂₁BNOP
Molecular Weight	297.14 g/mol
Synonyms	(-)-2,5-Diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine-borane; (2S,4R,5S)-2,5-Diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine 2-borane; Chiral Oxazaphospholidine-Borane Complex; (S,R,S)-DIPAMP Analogue Borane Adduct; (2S,4R,5S)-DPM-Oxazaphospholidine-BH₃; Borane-(2S,4R,5S)-2,5-diphenyl-3,4-dimethyl-1,3,2-oxazaphospholidine Complex
EINECS	Contact for details

Quality Control

Our production of (2S,4R,5S)-(-)-2,5-Diphenyl-3,4-Dimethyl-1,3,2-Oxazaphospholidine-2-Borane adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including Chiral HPLC, ¹H/³¹P/¹¹B NMR, and specific optical rotation measurement. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Optical Rotation [α]₂₀D	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.