Description

1-Chloroisoquinoline-7-carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique molecular structure, featuring both a reactive chlorine atom and a nitrile group on the isoquinoline scaffold, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and advanced polymers due to its rigid, planar structure and functional handles.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution (SNAr) to introduce the isoquinoline moiety into more complex molecules.
• Academic & R&D: A valuable reagent for methodological studies and the exploration of new synthetic pathways in heterocyclic chemistry.

Basic Information

Product Name	1-Chloroisoquinoline-7-carbonitrile
CAS No.	223671-30-5
Molecular Formula	C10H5ClN2
Molecular Weight	188.61 g/mol
Synonyms	7-Cyano-1-chloroisoquinoline; 1-Chloro-7-cyanoisoquinoline; Isoquinoline-7-carbonitrile, 1-chloro-; 1-Chloroisoquinoline-7-carbonitrile; 223671-30-5; 1-Chloro-7-isoquinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-Chloroisoquinoline-7-carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.