Description

6-Bromoisoquinoline 2-Oxide is a versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both an N-oxide and a bromine substituent, makes it a valuable precursor for constructing complex molecules through cross-coupling and functional group transformations. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and pesticides, where its bromine atom facilitates further derivatization.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and conductive polymers, due to its electron-rich isoquinoline core.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Functional Group Manipulation: The N-oxide group can be reduced or used to direct further functionalization, enabling diverse chemical modifications.

Basic Information

Product Name	6-Bromoisoquinoline 2-Oxide
CAS No.	223671-16-7
Molecular Formula	C9H6BrNO
Molecular Weight	224.06 g/mol
Synonyms	6-Bromoisoquinoline N-Oxide; Isoquinoline, 6-bromo-, 2-oxide; 6-Bromo-2-isoquinolinol 2-oxide; 6-Bromo-isoquinoline-2-oxide; 6-Bromoisoquinoline 2-oxide; 6-Bromoisoquinoline-2-oxide; 6-Bromoisoquinoline-2-oxide (6-Bromoisoquinoline N-Oxide)
EINECS	Contact for details

Quality Control

Our 6-Bromoisoquinoline 2-Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.