Description

1-(4-Chloro-7-(Pyrrolidin-1-Ylsulfonyl)Isoquinolin-1-Yl)Guanidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound matters for its role as a key building block in the synthesis of novel therapeutic agents, particularly those targeting specific enzymatic pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new chemical entities, especially within oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel small-molecule drug candidates.
• Kinase Inhibitor Research: Serves as a core scaffold for the development of potent and selective kinase inhibitors, a major class of targeted cancer therapies.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening and biochemical assays.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and pharmacology.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's outsourced R&D and production needs.

Basic Information

Product Name	1-(4-Chloro-7-(Pyrrolidin-1-Ylsulfonyl)Isoquinolin-1-Yl)Guanidine Hydrochloride
CAS No.	223671-05-4
Molecular Formula	C₁₄H₁₇Cl₂N₅O₂S
Molecular Weight	394.29 g/mol
Synonyms	1-(4-Chloro-7-(pyrrolidine-1-sulfonyl)isoquinolin-1-yl)guanidine hydrochloride; 1-(4-Chloro-7-(pyrrolidin-1-ylsulfonyl)isoquinolin-1-yl)guanidine HCl; Guanidine, N-[4-chloro-7-(1-pyrrolidinylsulfonyl)-1-isoquinolinyl]-, monohydrochloride; 223671-05-4; 4-Chloro-7-(pyrrolidin-1-ylsulfonyl)-1-(diaminomethylideneamino)isoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-7-(Pyrrolidin-1-Ylsulfonyl)Isoquinolin-1-Yl)Guanidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and regulatory compliance ensures a reliable supply for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.