Description

Cyclohexanethiol,5-Methyl-2-(1-Methylethyl)-,(1R,2R,5S)-Rel-(9Ci) is a high-purity, chiral thiol derivative of menthol, distinguished by its specific stereochemistry. This compound matters as a versatile and valuable chiral building block for the synthesis of complex molecules, particularly in the pharmaceutical and fine chemical industries. It is needed by R&D chemists and process development scientists for applications in asymmetric synthesis, ligand development, and the creation of active pharmaceutical ingredients (APIs) where precise stereochemical control is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring specific stereochemistry.
• Asymmetric Catalyst Ligand: Used in the preparation of chiral ligands for transition metal catalysis, enabling enantioselective transformations in fine chemical synthesis.
• Flavor and Fragrance Chemistry: Serves as a precursor for synthesizing sulfur-containing aroma compounds with minty or thiolic notes, leveraging its menthol-related structure.
• Agrochemical Synthesis: Employed as a building block in the development of chiral pesticides and herbicides, where biological activity is often stereospecific.
• Material Science Research: Investigated for use in creating functionalized surfaces or polymers where the thiol group provides a handle for attachment via thiol-ene chemistry.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and verification in chiral analysis.

Basic Information

Product Name	Cyclohexanethiol,5-Methyl-2-(1-Methylethyl)-,(1R,2R,5S)-Rel-(9Ci)
CAS No.	223653-15-4
Molecular Formula	C10H20S
Molecular Weight	172.33 g/mol
Synonyms	(1R,2R,5S)-5-Methyl-2-(1-methylethyl)cyclohexanethiol; (-)-Menthyl Mercaptan; (1R,2R,5S)-(-)-Menthyl Mercaptan; rel-(1R,2R,5S)-5-Methyl-2-(propan-2-yl)cyclohexane-1-thiol; 2-Isopropyl-5-methylcyclohexanethiol (stereoisomer); Thioisomenthol; L-Menthyl Mercaptan; Thiomenthol derivative
EINECS	Contact for details

Quality Control

Our Cyclohexanethiol,5-Methyl-2-(1-Methylethyl)-,(1R,2R,5S)-Rel-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by GC or HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.