Description

(R)-(1-Methyl-2-Tritylisoindolin-5-Yl)Boronic Acid is a high-value, chiral boronic acid derivative used as a critical synthetic intermediate. Its primary commercial value lies in its role as a key building block for the synthesis of complex, optically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for forming carbon-carbon bonds, enabling the construction of complex molecular architectures.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to develop new compounds with improved efficacy and selectivity.
• Asymmetric Synthesis: Leverages its chiral isoindoline scaffold for the preparation of enantiomerically pure compounds, which is vital for producing single-isomer drugs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for advanced pharmaceutical intermediates.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and inhibitors for studying biological pathways and target validation.

Basic Information

Product Name	(R)-(1-Methyl-2-Tritylisoindolin-5-Yl)Boronic Acid
CAS No.	223595-19-5
Molecular Formula	C29H28BNO2
Molecular Weight	433.35 g/mol
Synonyms	(R)-1-Methyl-2-trityl-5-isoindolinylboronic acid; (R)-1-Methyl-2-triphenylmethyl-1,2-dihydroisoindol-5-ylboronic acid; (R)-5-Borono-1-methyl-2-tritylisoindoline; (R)-N-Methyl-2-tritylisoindolin-5-ylboronic acid; (R)-(1-Methyl-2-Trityl-1,2-dihydroisoindol-5-yl)boronic Acid; (R)-1-Methyl-2-(triphenylmethyl)-1,2-dihydro-3H-isoindol-5-ylboronic acid; (R)-Methyltritylisoindolinylboronic Acid
EINECS	Contact for details

Quality Control

Our (R)-(1-Methyl-2-Tritylisoindolin-5-Yl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with stringent specifications for pharmaceutical R&D use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.