Description

(1R)-5-Bromo-2,3-Dihydro-1-Methyl-1H-Isoindole CAS NO 223595-17-3 is a high-purity, chiral isoindoline derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in its specific stereochemistry and bromine functionality, enabling the construction of complex, biologically active molecules. This advanced intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Key chiral intermediate in the synthesis of novel central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Building block for the development of protease inhibitors and other enzyme-targeted therapeutics.
• Precursor in the research and scale-up of agrochemicals, including pesticides and herbicides with specific stereochemical requirements.
• Versatile starting material for asymmetric synthesis in academic and industrial research laboratories.
• Intermediate in the production of specialty fine chemicals and custom synthesis projects.
• Used in the development of molecular probes and diagnostic agents for biochemical research.

Basic Information

Product Name	(1R)-5-Bromo-2,3-Dihydro-1-Methyl-1H-Isoindole
CAS No.	223595-17-3
Molecular Formula	C9H10BrN
Molecular Weight	212.09 g/mol
Synonyms	(R)-5-Bromo-1-methyl-2,3-dihydro-1H-isoindole; (1R)-5-Bromo-1-methylisoindoline; 5-Bromo-1-methyl-2,3-dihydro-1H-isoindole, (R)-; (R)-5-Bromo-1-methylisoindoline; 1H-Isoindole, 5-bromo-2,3-dihydro-1-methyl-, (1R)-; (R)-5-Bromo-2,3-dihydro-1-methyl-1H-isoindole; (1R)-5-Bromo-1-methyl-2,3-dihydro-1H-isoindole
EINECS	Contact for details

Quality Control

Our (1R)-5-Bromo-2,3-Dihydro-1-Methyl-1H-Isoindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles. We support development and commercial projects with material suitable for use under cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.