Description

1-(4-Methylphenyl)-4,5,6,7-Tetrahydro-1H-Indazole-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the indazole carboxylic acid class. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and inflammation. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Kinase Inhibitor Development: Serves as a core scaffold for the development of selective kinase inhibitors, a major class in oncology therapeutics.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Biochemical Research: Used in vitro studies to investigate biological activity and mechanism of action.
• Custom Synthesis: Starting material for the custom synthesis of more complex, target-specific molecules for preclinical development.

Basic Information

Product Name	1-(4-Methylphenyl)-4,5,6,7-Tetrahydro-1H-Indazole-3-Carboxylic Acid
CAS No.	223444-60-8
Molecular Formula	C15H16N2O2
Molecular Weight	256.30 g/mol
Synonyms	1-(p-Tolyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid; 1-(4-Methylphenyl)-4,5,6,7-tetrahydroindazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-1-(4-methylphenyl)-; 223444-60-8; 1-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid; 1-(4-Methylphenyl)-4,5,6,7-tetrahydroindazole-3-carboxylic acid; 1-(p-Methylphenyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) are available upon request, providing full transparency on specifications such as assay, related substances, and residual solvents. We adhere to a cGMP-compliant quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.