Description

Methyl 1-Chloro-4-Hydroxyisoquinoline-3-Carboxylate is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound is valued for its reactive chloro and ester functional groups, which enable its use as a key intermediate in the development of complex molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel isoquinoline-based drug candidates, including potential kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for biological activity.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing complex polycyclic structures in academic and industrial R&D laboratories.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and functional organic materials.
• Chemical Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	Methyl 1-Chloro-4-Hydroxyisoquinoline-3-Carboxylate
CAS No.	223388-20-3
Molecular Formula	C11H8ClNO3
Molecular Weight	237.64 g/mol
Synonyms	1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid methyl ester; Methyl 1-chloro-4-oxo-1,4-dihydroisoquinoline-3-carboxylate; 1-Chloro-4-hydroxy-3-methoxycarbonylisoquinoline; 3-Carbomethoxy-1-chloro-4-hydroxyisoquinoline; 1-Chloro-4-hydroxy-3-isoquinolinecarboxylic acid methyl ester; 223388-20-3; Methyl 1-chloro-4-hydroxy-3-isoquinolinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1-Chloro-4-Hydroxyisoquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.