Description

2,3,3,3-Tetradeuterio-n-[4-Nitro-3-(Trifluoromethyl)Phenyl]-2-(Trideuteriomethyl)Propanamide is a deuterated isotopologue of a key pharmaceutical intermediate, offering enhanced metabolic stability and traceability for advanced research and development. This compound is specifically engineered for use in mass spectrometry, pharmacokinetic studies, and as an internal standard for quantitative bioanalytical assays. It is an essential material for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and development, particularly for compounds targeting the androgen receptor.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, isotopically labeled internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track drug disposition and metabolic pathways with high specificity.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and accurate analytical methods in compliance with FDA and EMA guidelines.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during API (Active Pharmaceutical Ingredient) development.
• Mechanistic Studies: Enables detailed investigation of biochemical mechanisms and receptor-ligand interactions without interference from endogenous compounds.

Basic Information

Product Name	2,3,3,3-Tetradeuterio-n-[4-Nitro-3-(Trifluoromethyl)Phenyl]-2-(Trideuteriomethyl)Propanamide
CAS No.	223134-72-3
Molecular Formula	C11H7D6F3N2O3
Molecular Weight	290.25 g/mol (for deuterated form)
Synonyms	Deuterated Bicalutamide-d6; Bicalutamide-d6; 2,3,3,3-Tetradeutero-N-[4-nitro-3-(trifluoromethyl)phenyl]-2-(trideuteriomethyl)propanamide; N-[4-Nitro-3-(trifluoromethyl)phenyl]-2-(methyl-d3)-3,3,3-trideuterio-2-methylpropanamide; Casodex-d6; Androgen Receptor Antagonist-d6; (RS)-N-[4-Nitro-3-(trifluoromethyl)phenyl]-2-(methyl-d3)-3,3,3-trideuterio-2-methylpropanamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity, essential for reliable analytical data. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container tightly sealed to prevent moisture absorption and potential isotopic exchange.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.