Description

4-(Trimethylsilyl)Thiophen-2-Ylboronic Acid is a high-value organoboron building block, specifically a thiophene-substituted boronic acid derivative protected with a trimethylsilyl group. This compound is critical for enabling complex cross-coupling reactions, such as Suzuki-Miyaura couplings, where its unique structure provides enhanced stability and reactivity control. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel heterocyclic compounds and functionalized thiophene-based molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex thiophene or fused heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific thiophene-based architectures.
• Material Science & OLED Development: Employed in the creation of organic semiconductors, conductive polymers, and light-emitting materials for electronic devices and displays.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, enabling the construction of complex organic molecules.
• Chemical Research & Development: Serves as a versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities.
• Ligand Synthesis: Can be used as a precursor for synthesizing specialized ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	4-(Trimethylsilyl)Thiophen-2-Ylboronic Acid
CAS No.	222840-90-6
Molecular Formula	C9H15BO2SSi
Molecular Weight	226.19 g/mol
Synonyms	2-Borono-4-(trimethylsilyl)thiophene; 4-(Trimethylsilyl)-2-thienylboronic Acid; (4-Trimethylsilylthiophen-2-yl)boronic Acid; 2-(4-Trimethylsilyl)thienylboronic Acid; 4-TMS-Thiophene-2-boronic Acid; TMS-Thiophene Boronic Acid; B-[4-(Trimethylsilyl)-2-thienyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsilyl)Thiophen-2-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.