Description

2-[2-(4-Fluorophenyl)-2-Oxo-1-(2,3,4,5,6-Pentadeuteriophenyl)Ethyl]-4-Methyl-3-Oxo-n-Phenylpentanamide is a high-purity, deuterated organic compound of significant interest in advanced research and development. This compound is valued for its role as a stable isotope-labeled internal standard, which is critical for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) working in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterium-labeled reference compound for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic and metabolic stability assays to track drug candidates and their metabolites with high specificity, minimizing interference from endogenous compounds.
• Bioanalytical Method Development: Essential for validating robust, sensitive, and selective analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Impurity Identification and Profiling: Aids in the identification and quantification of process-related impurities and degradants during active pharmaceutical ingredient (API) development.
• Stable Isotope Dilution Mass Spectrometry (SID-MS): Employed in this gold-standard technique for achieving the highest level of quantitative accuracy in proteomics, metabolomics, and clinical chemistry.
• Pharmaceutical R&D: Supports discovery and development pipelines for new chemical entities, particularly in oncology, neurology, and metabolic disease research.

Basic Information

Product Name	2-[2-(4-Fluorophenyl)-2-Oxo-1-(2,3,4,5,6-Pentadeuteriophenyl)Ethyl]-4-Methyl-3-Oxo-n-Phenylpentanamide
CAS No.	222412-75-1
Molecular Formula	C26H20D5FNO3
Molecular Weight	Contact for details
Synonyms	2-[2-(4-Fluorophenyl)-2-oxo-1-(pentadeuteriophenyl)ethyl]-4-methyl-3-oxo-N-phenylpentanamide; Deuterated Atorvastatin Lactone-d5 (related analog); (3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid-d5 Lactone (structural variant); Pentadeutero-phenyl Labeled Compound; Internal Standard for Fluorophenyl Ketone Analogs; Stable Isotope-Labeled Amide; NMR & MS Reference Standard.
EINECS	Contact for details

Quality Control

Every batch of this deuterated compound is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for analytical reference standards. Comprehensive testing includes identity confirmation by spectroscopic methods (NMR, IR, MS), purity assessment by HPLC, and verification of deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Keep the container in a dry, well-ventilated area dedicated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.