Description

1-(2-Chloro-4-Methylthiazol-5-Yl)Ethan-1-One is a high-purity, specialized heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique thiazole core structure is essential. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole moiety.
• Material Science Research: Employed as a building block for developing novel organic electronic materials, ligands for catalysis, and specialty polymers.
• Chemical Biology & Proteomics: Serves as a valuable scaffold or tagging reagent in the design of molecular probes and enzyme inhibitors for biological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	1-(2-Chloro-4-Methylthiazol-5-Yl)Ethan-1-One
CAS No.	222169-16-6
Molecular Formula	C6H6ClNOS
Molecular Weight	175.63 g/mol
Synonyms	2-Chloro-4-methyl-5-acetylthiazole; 5-Acetyl-2-chloro-4-methylthiazole; 1-(2-Chloro-4-methyl-1,3-thiazol-5-yl)ethanone; Ethanone, 1-(2-chloro-4-methyl-5-thiazolyl)-; 2-Chloro-4-methylthiazole-5-yl methyl ketone; 5-Acetyl-2-chloro-4-methyl-1,3-thiazole
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-4-Methylthiazol-5-Yl)Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.