Description

n-(5-Aminopentyl)Maleimide Trifluoroacetate Salt is a high-purity, bifunctional chemical linker featuring a reactive maleimide group and a primary amine, protected as a stable trifluoroacetate salt. This compound is essential for the site-specific conjugation of biomolecules, enabling the creation of stable thioether bonds with sulfhydryl groups while offering a primary amine for further modification or coupling. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, peptide synthesis, and advanced materials science, where precise and stable cross-linking is required.

Application

• Bioconjugation and ADC Linker: A key building block for constructing antibody-drug conjugates (ADCs) and protein-drug conjugates via its maleimide-thiol chemistry.
• Peptide Modification and Labeling: Used to introduce maleimide functionality into peptides or other amine-containing molecules for subsequent labeling or cross-linking.
• Surface Functionalization: Employed to modify surfaces, nanoparticles, or polymers with reactive maleimide groups for biomolecule immobilization.
• Cross-linking Agent: Serves as a heterobifunctional cross-linker to bridge amine-containing and thiol-containing molecules in biochemical assays and material synthesis.
• Proteomics Research: Utilized in activity-based protein profiling and other chemical proteomics strategies to tag and study proteins.
• Diagnostic Reagent Synthesis: A precursor for synthesizing reagents used in immunoassays and diagnostic kits.

Basic Information

Product Name	n-(5-Aminopentyl)Maleimide Trifluoroacetate Salt
CAS No.	222159-87-7
Molecular Formula	C11H15F3N2O4
Molecular Weight	296.25 g/mol
Synonyms	5-Maleimidopentylamine Trifluoroacetate; N-(5-Aminopentyl)maleimide TFA Salt; 1-(5-Aminopentyl)-1H-pyrrole-2,5-dione Trifluoroacetate; 5-Maleimidopentylammonium Trifluoroacetate; Maleimidocaproic acid amine TFA salt; N-(5-Aminoamyl)maleimide trifluoroacetate; Aminopentyl Maleimide TFA Salt
EINECS	Contact for details

Quality Control

Our n-(5-Aminopentyl)Maleimide Trifluoroacetate Salt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and bioconjugation applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.