Description

1,2-Benzisothiazole-5-Carboxylic Acid, 2,3-Dihydro-3-Oxo-, 1,1-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzisothiazole dioxide core structure. This compound is of significant commercial importance as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical manufacturers engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and anti-inflammatory pathways.
• Agrochemical Research: Serves as a versatile scaffold for developing new herbicides and fungicides with novel modes of action.
• Material Science: Used in the research and development of specialty polymers and advanced organic electronic materials due to its fused heterocyclic system.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex molecules, leveraging its reactive carboxylic acid and sulfone functionalities.
• Bioconjugation & Probe Development: The carboxylic acid group allows for coupling to biomolecules, making it useful for creating diagnostic probes and biochemical tools.

Basic Information

Product Name	1,2-Benzisothiazole-5-Carboxylic Acid, 2,3-Dihydro-3-Oxo-, 1,1-Dioxide
CAS No.	221446-00-0
Molecular Formula	C8H5NO5S
Molecular Weight	227.19 g/mol
Synonyms	3-Oxo-2,3-dihydro-1,2-benzisothiazole-5-carboxylic acid 1,1-dioxide; 1,2-Benzisothiazolin-3-one-5-carboxylic acid 1,1-dioxide; Saccharin-6-carboxylic acid; 6-Carboxysaccharin; 5-Carboxy-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; 2,3-Dihydro-3-oxo-1,2-benzisothiazole-5-carboxylic acid 1,1-dioxide
EINECS	Contact for details

Quality Control

Our production of 1,2-Benzisothiazole-5-Carboxylic Acid, 2,3-Dihydro-3-Oxo-, 1,1-Dioxide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured and tested in facilities that follow cGMP principles where applicable. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. Our quality systems are designed to meet the exacting standards required for pharmaceutical R&D and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.