Description

L-Phenylalanine-3,3-D2 is a stable isotope-labeled analog of the essential amino acid L-Phenylalanine, specifically deuterated at the 3,3 positions. This precise labeling makes it an indispensable tool for advanced research in metabolic studies, proteomics, and pharmaceutical development, where it serves as an internal standard for accurate quantification. It is primarily required by research institutions, pharmaceutical companies, and CROs engaged in mass spectrometry, NMR spectroscopy, and the development of novel therapeutics and diagnostic agents.

Application

• Mass Spectrometry Internal Standard: Used as a quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate measurement of endogenous phenylalanine and related metabolites in biological samples.
• Metabolic Pathway Tracing: Employed in metabolic flux analysis and pharmacokinetic studies to track the incorporation and fate of phenylalanine in vivo and in vitro.
• Proteomics Research: Facilitates protein quantification and turnover studies using stable isotope labeling by amino acids in cell culture (SILAC) and other labeling techniques.
• NMR Spectroscopy: Serves as a deuterated probe in nuclear magnetic resonance studies to simplify complex spectra and investigate molecular structure and dynamics.
• Pharmaceutical Development: Critical in the research and quality control of deuterated drug candidates, where deuterium incorporation is used to modify pharmacokinetic properties.
• Clinical Diagnostics: Potential use in developing assays for metabolic disorders such as phenylketonuria (PKU).

Basic Information

Product Name	L-Phenylalanine-3,3-D2
CAS No.	221346-31-2
Molecular Formula	C9H9D2NO2
Molecular Weight	167.20 g/mol
Synonyms	(2S)-2-Amino-3-(3,3-dideuteriophenyl)propanoic acid; L-Phenylalanine-d2 (3,3-D2); Phenylalanine-3,3-d2; (S)-2-Amino-3-(3,3-d2-phenyl)propionic acid; F-d2; Phe-d2; L-3,3-Dideuteriophenylalanine; Stable Isotope Labeled L-Phenylalanine
EINECS	Contact for details

Quality Control

Our L-Phenylalanine-3,3-D2 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR, MS, and HPLC to confirm identity, purity, and deuterium enrichment. Certificates of Analysis (COA) detailing all specifications are provided to guarantee reproducibility and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Optical Rotation	[α]20/D: -33° to -36° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.