Description

20-(11-Mercaptoundecanoyl)-3,6,9,12,18-Hexaoxaeicosanoicacid is a specialized bifunctional molecule featuring a terminal thiol (mercapto) group and a carboxylic acid, linked by a hydrophilic polyethylene glycol (PEG) spacer chain. This unique structure makes it an essential heterobifunctional linker for advanced bioconjugation, surface functionalization, and the creation of self-assembled monolayers (SAMs). It is critically needed by researchers and manufacturers in the pharmaceutical, nanotechnology, and diagnostics sectors for developing targeted drug delivery systems, biosensors, and biocompatible coatings.

Application

• Bioconjugation and Protein/Peptide Modification: The thiol and carboxyl groups enable site-specific coupling to biomolecules for creating antibody-drug conjugates (ADCs) or labeled proteins.
• Surface Functionalization of Nanoparticles and Quantum Dots: Used to attach targeting ligands or PEGylate surfaces to improve stability and biocompatibility of nanocarriers.
• Formation of Self-Assembled Monolayers (SAMs) on Gold Surfaces: The thiol group anchors the molecule to gold, creating ordered surfaces with terminal carboxylic acid groups for subsequent chemical attachment in biosensor development.
• Polymer and Hydrogel Synthesis: Acts as a crosslinker or functional monomer to introduce reactive thiol or acid groups into polymer backbones for controlled drug release systems.
• Diagnostic Assay Development: Facilitates the immobilization of capture antibodies or antigens onto sensor chips and microplates via the carboxylic acid group.
• Material Science and Nanofabrication: Employed in the precise patterning and functionalization of surfaces for electronic and biomedical devices.

Basic Information

Item	Detail
Product Name	20-(11-Mercaptoundecanoyl)-3,6,9,12,18-Hexaoxaeicosanoicacid
CAS No.	221222-49-7
Molecular Formula	C27H52O9S
Molecular Weight	552.77 g/mol
Synonyms	11-Mercaptoundecanoic acid, ω-carboxy-PEG5-thiol; HS-PEG5-COOH; α-Thio-ω-carboxy hexaethylene glycol; Thiol-PEG5-acid; 20-(11-Mercaptoundecanoyl)-3,6,9,12,15,18-hexaoxaeicosanoic acid; Heterobifunctional PEG linker, thiol and carboxyl; Carboxy-PEG5-thiol; 3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-(11-mercaptoundecanoyl)-
EINECS	Contact for details

Quality Control

Our production of 20-(11-Mercaptoundecanoyl)-3,6,9,12,18-Hexaoxaeicosanoicacid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and FT-IR to confirm structure, purity, and functional group integrity. A comprehensive Certificate of Analysis (COA) detailing assay, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its thiol group, this compound is easily oxidized and should be stored under an inert atmosphere (argon or nitrogen) when possible. For long-term stability, store desiccated at -20°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by Thiol Titration)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.