Description

3-(2,5-Dioxo-Pyrrolidin-1-Yl)-Propionic Acid is a versatile chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester moiety linked to a propionic acid spacer. This compound matters for its ability to facilitate efficient bioconjugation and cross-linking reactions, enabling the stable attachment of molecules to amino groups under mild aqueous conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing novel therapeutics, diagnostic assays, and advanced biomaterials.

Application

• Bioconjugation Reagent: For the covalent coupling of peptides, proteins, antibodies, and other biomolecules to carriers, surfaces, or other functional molecules.
• Cross-linking Agent: Used in the synthesis of hydrogels, polymer networks, and drug delivery systems requiring stable amide bond formation.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs).
• Diagnostic Probe Synthesis: Enables the labeling of detection molecules (e.g., enzymes, fluorescent dyes) for use in ELISA, immunoassays, and biosensors.
• Surface Functionalization: Used to modify nanoparticles, microplates, and sensor chips with amine-reactive groups for subsequent biomolecule immobilization.
• Material Science: Employed in the development of functionalized polymers and smart materials with specific biological activity.

Basic Information

Product Name	3-(2,5-Dioxo-Pyrrolidin-1-Yl)-Propionic Acid
CAS No.	220753-47-9
Molecular Formula	C7H9NO5
Molecular Weight	187.15 g/mol
Synonyms	N-(3-Carboxypropionyl)succinimide; 3-(N-Succinimidyl)propionic Acid; 3-(2,5-Dioxopyrrolidin-1-yl)propanoic Acid; NHS-Propionic Acid; Succinimidyl Propionate; 1-(2-Carboxyethyl)pyrrolidine-2,5-dione; Propanoic acid, 3-(2,5-dioxo-1-pyrrolidinyl)-
EINECS	Contact for details

Quality Control

Our 3-(2,5-Dioxo-Pyrrolidin-1-Yl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and FTIR are provided to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. Keep away from strong bases and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.